Disclosures: Membership on Advisory Committees or Review Panels, Board Membership, etc.-Clinical Innovations|Stocks or stock options, excluding diversified mutual funds-Sera Prognostics - 03/10/2022

CURRICULUM VITAE

December 2019

PERSONAL DATA

Name: M. Sean Esplin, MD

Place of Birth: Provo, Utah

Citizenship: United States

BUSINESS ADDRESS / CONTACT INFORMATION

Office Address: Intermountain Medical Center

Maternal-Fetal Medicine

5121 S. Cottonwood Street

Suite 100

Murray, Utah 84107-5701

Office: 801.507.7431

Fax: 801-507-7494

sean.esplin@imail.org

EDUCATION

1984 - 1989 BS Brigham Young University (Zoology)

Provo, UT

1989 - 1993 MD University of Utah Hospital School of Medicine (Medicine)

Salt Lake City, UT

1993 – 1994 Intern University of Utah School of Medicine (Ob/Gyn)

Salt Lake City, UT

1994 - 1997 Resident University of Utah School of Medicine (Ob/Gyn)

Salt Lake City, UT

1997 – 2000 Fellow University of Utah School of Medicine (Maternal-Fetal Medicine)

Salt Lake City, UT

2001 Woods Hole Symposium

“Frontier in Reproduction”

Woods Hole, MA

BOARD CERTIFICATIONS

12/13/2002 American Board of Obstetrics and Gynecology (Obstetrics and Gynecology), Certified

04/07/2005 American Board of Obstetrics and Gynecology (Sub: Maternal-Fetal Medicine), Certified

LICENSES/CERTIFICATIONS

1999 – Present Controlled Substance (UT) – Physician (MD)

1999 – Present State License (UT) – Physician (MD)

2004 – Present DEA Certificate (UT) – Physician (MD)

ACADEMIC HISTORY

Obstetrics/Gynecology (Maternal-Fetal Medicine)

12/12/1997 Hire, Instructor Track, Instructor, University of Utah Health Sciences Center

7/1/2000 Instructor Appt Not Counted, University of Utah Health Sciences Center

7/1/2000 Tenure Track – Clinician Scholar, Assistant Professor, University of Utah Health Sciences Center

7/1/2007 Promotion, Associate Professor, University of Utah Health Sciences Center

7/1/2007 Tenure

7/1/2014 Promotion, Professor, University of Utah Health Sciences Center

12/2/19 Appointment, Professor, Clinician Investigator Track, Intermountain Healthcare

UUHC Community Physician Group

8/2/1997 - 6/11/2000 Hire, UUHC Track, UUHC Employed Physician

PROFESSIONAL EXPERIENCE

Full Time Positions

1996-2007 Medical Director, South Main Clinic, Salt Lake City, UT

1997-2000 Limited Term Instructor, University of Utah Health Sciences Center, Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Salt Lake City, UT

2000-Present Attending Physician, Maternal-Fetal Medicine, Intermountain Healthcare, Salt Lake City, UT

2000-2007 Assistant Professor, University of Utah Health Sciences Center, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Salt Lake City, UT

2007-2014 Associate Professor, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Utah, Salt Lake City, UT

2014-Present Professor, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Utah, Salt Lake City, UT

2008-2017 Research Director, Maternal-Fetal Medicine, Intermountain Medical Center, Salt Lake City, UT

2104-Present Director, Maternal Intervention Committee, Utah Women and Newborn Quality Collaborative, Salt Lake City UT

2017-Present Chair, Women and Newborn Research Group, Intermountain Healthcare

2017-Present Chairman, Department of Obstetrics and Gynecology, Intermountain Medical Center, Salt Lake City, UT

Reviewer Experience

Reviewer for American Journal of Obstetrics and Gynecology

Reviewer for British Journal of Obstetrics and Gynecology

Reviewer for Institute of Medicine preterm Birth Causes: Consequence and prevention. Report by the committee to understand premature birth and assuring health outcomes. 2006

Reviewer for New England Journal of Obstetrics and Gynecology

Reviewer for Obstetrics and Gynecology

SCHOLASTIC HONORS

1984 – 1989 Trustees Scholarship, Brigham Young University, Provo, UT

1989 Phi Kappa Phi Honor Society, Brigham Young University, Provo, UT

1991 National Research Fellowship, Epilepsy Foundation of America

1992 AOA Honor Society, University of Utah School of Medicine

1993 Michael Whorley Award, University of Utah School of Medicine

1993 Golden Cane Award, University of Utah School of Medicine

1994 Winner of National Resident Writing contest, The Journal of Clinical Practice in Human Sexuality

1996-1997 Resident Teaching Award

2007-2008 Resident Teaching Award

2011 APGO Excellence in Teaching Award, voted by 3rd year medical students (Association of Professors of Gynecology and Obstetrics)

2011 CREOG Excellence in Teaching Award

2016 APGO Excellence in Teaching Award, voted by 3rd year medical students (Association of Professors of Gynecology and Obstetrics)

2016 Excellence in Medicine and Patient Care, Intermountain Medical Center, Salt Lake City, UT

2017 American Journal of Obstetrics & Gynecology Research Excellence Award

2017 University of Utah School of Medicine Outstanding Clinical Faculty Award

2017 Healthcare Heroes, Intermountain Medical Center, Salt Lake City, UT

ADMINISTRATIVE EXPERIENCE

Administrative Duties

1996-2007 Medical Director, South Main Clinic, Salt Lake City, UT

2001-Present Member, Intermountain UCR IRB Committee

2003-2018 Resident Research Coordinator

2005-Present Member, Intermountain Corporate IRB Committee

2008-2018 Member, Scholarly Activities Committee, Society for Maternal-Fetal Medicine

2008-2017 Research Director, Women and Newborn Research Group, Intermountain Medical Center, Murray, UT

2011-Present Member, Intermountain Deseret Foundation Research Committee

2013-Present Chair, Maternal Intervention Committee, Utah Women and Newborn Quality Collaborative, Utah Department of Health

2017-Present Chair, Department of Obstetrics and Gynecology, Intermountain Medical Center

2017-Present Chair, Women and Newborn Research Group, Intermountain Healthcare

2018-Present Research Guidance Council Member, Intermountain Healthcare

Professional Organization & Scientific Activities

2008-Present Member, Society for Maternal-Fetal Medicine, Scholarly Activities Committee

2012 Invited Speaker, Society of Maternal-Fetal Medicine, Annual Postgraduate Course, San Francisco,

2017 Invited Speaker, Society of Maternal-Fetal Medicine, Annual Postgraduate Course, San Francisco,

2018-Present Examiner Oral Boards, Maternal Fetal Medicine Subspecialty, American Board of Obstetrics and Gynecology

Symposium/Meeting Chair/Coordinator

2010-2018 Chair of James R. and Joe Scott Society, Annual Research Symposium

2012-Present Meeting Chair, Utah Prematurity Symposium

2012-Present Meeting Coordinator, Reach Out and Learn, Conference on Women’s Health, Cusco, Peru

PROFESSIONAL COMMUNITY ACTIVITIES

2011-Present Member, Intermountain Medical and Research Foundation Research Committee

2013-Present Chair, Maternal Intervention Committee, Utah Women and Newborn Quality Collaborative, Utah Department of Health

SERVICE AT AFFILIATED INSTITUTIONS

2001-Present Member, Intermountain UCR IRB Committee

2005-Present Member, Intermountain Corporate IRB Committee

2008-2018 Resident Research Director, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, UT

SERVICE AT PREVIOUS INSTITUTIONS

2000-2018 Invited Speaker, Brigham Young University, Annual Undergraduate Biology Application Course

2010-Present Host, Brigham Young University, Premedical student physician shadowing program

CURRENT MEMBERSHIPS IN PROFESSIONAL SOCIETIES

Alpha Omega Alpha

American Medical Association

Society for Maternal-Fetal Medicine

Utah Medical Association

FUNDING

Active Grants

01/01/09 – Present Maternal Fetal Medicine Units Network

Principal Investigator(s): Michael Varner; M. Sean Esplin

National Institute of Child Health and Human Development

Direct Costs: $ Total Costs: $

Role: Site-Principal Investigator, Intermountain Healthcare

3/25/09 – Present Identification of Genes Associated with Prematurity

Principal Investigator(s): M. Sean Esplin; G. Marc Jackson

Direct Costs: $40,000 Total Costs: $40,000

Deseret Foundation

Role: Co-Principal Investigator

10/01/09 – Present Establishment of a Comprehensive, Collaborative Adverse Pregnancy Outcomes

Principal Investigator(s): M. Sean Esplin; G. Marc Jackson

Direct Costs: $25,000 Total Costs: $25,000

University of Utah Center for Clinical and Translational Science

Role: Co-Principal Investigator

11/17/09 – Present Evaluation of Electronic Fetal Monitoring and Relationship to

Neonatal Outcomes.

Principal Investigator: M. Sean Esplin

Direct Costs: $25,000 Total Costs: $25,000

Deseret Foundation

Role: Co-Principal Investigator

1/01/12 – Present Cardiac Biomarkers in Peripartum Cardiomyopathy and Preeclampsia

Principal Investigator(s): R. Alharethi; M. Sean Esplin

Direct Costs: $76,442 Total Costs: $76,442

Deseret Foundation

Role: Co-Principal Investigator

5/01/18 – Present Novii Trial:

Principal Investigator(s): M. Sean Esplin, martha Monson

Direct Costs: $ 100,000 Total Costs: $100,000

Industry Sponsored: General Electric

Role: Principal Investigator

5/01/18 – Present PREVENT PTB Trial:

Principal Investigator(s): D. Ware Branch; M. Sean Esplin

Direct Costs: $ Total Costs: $

Industry Sponsored: Sera Prognostics

Role: Co-Principal Investigator

Past Grants

7/01/99 – 6/30/04 Utah WRHR Career Development Center – 5K12HD01241-2

Principle Investigator: M. Sean Esplin

National Institute of Child Health and Human Development

Role: Principal Investigator

7/01/199 – 6/30/2001 The Identification and Characterization of Genes Unique to Labor. Closed 2-11-02

Principal Investigator: M. Sean Esplin

Direct Costs: $90,000 Total Costs: $90,000

Society for Maternal-Fetal Medicine

Role: Principal Investigator

1/01/05 – 12/31/05 South Main Clinic

Principal Investigator: M. Sean Esplin

Direct Costs: $75,000 Total: $7,500

March of Dimes Birth Defects Foundation

Role: Principal Investigator

4/01/05 – 5/31/08 Proteomics: A Novel Approach To Predicting Preeclampsia

Principal Investigator: M. Sean Esplin

Direct Costs: $300,678 Total Costs: $318,634

National Institutes of Health

Role: Principal Investigator

8/10/08 – 8/10/11 Proteomic Identification of Serum markers for Preeclampsia

Principal Investigator: M. Sean Esplin

Direct Costs: $40,000 Total Costs: $40,000

Deseret Foundation

Role: Principal Investigator

1/10/10 – 12/31/12 Preterm Birth in Nulliparous Women: An Understudied Population

National Institute of Child Health and Human Development

Role: Other Significant Contributor

11/01/05 – 01/31/11 Genomic and Proteomic Network for Premature Birth Research

Principal Investigator: M. Sean Esplin

National Institute of Child Health and Human Development

Role: Principal Investigator

TEACHING RESPONSIBILITIES

Course Lectures

2003 Instructor, PHYSL 6070(1): Physiology – Physiology of Labor and Delivery, University of Utah, Physiology

2006 Instructor, OBST 7020(1): Reproductive OS – Small Groups: PIH/OB Hemorrhage Workshop, University of Utah, Obstetrics/Gynecology

2007 Instructor, OBST 7020(1): Reproductive OS-6 – Physiology of Pregnancy, University of Utah, Obstetrics/Gynecology

2007 Instructor, OBST 7020(1): Reproductive OS-6 – Physiology of Labor and Delivery, University of Utah, Obstetrics/Gynecology

2009 Instructor, OBST 7020(1): Reproductive OS-6 – PIH/OB Hemorrhage Workshop, University of Utah, Obstetrics/Gynecology

2010 Instructor, OBST 7020(1): Reproductive OS-6 – PIH/OB Hemorrhage Workshop, University of Utah, Obstetrics/Gynecology

2010 Instructor, MD ID(1): Medical Science – Pregnancy, University of Utah, Deans Office - SOM

2010 Instructor, MD ID(1): Medical Science – Case Based Learning Exercise, University of Utah, Deans Office – SOM

2010 Instructor, MD ID(1): Medical Science – Pregnancy 2, University of Utah, Deans Office –SOM

2011-2012 Instructor(1): MS2013 OB/GYN Clerkship – Topics in Obstetrics #2 – Various OB subjects, University of Utah

2012 Instructor(1): MS2014 M+R – Pregnancy: 1, University of Utah.

2012 Instructor(1): MS2014 M+R – OB Small Group Activity – Developers, University of Utah.

2012 Instructor(1): MS2014 M+R – OB Small Group Activity – Facilitators, University of Utah

2012 Instructor(1): MS2014 M+R – Pregnancy: 2, University of Utah

2012-present Instructor(1): MS2013 OB/GYN Clerkship – Topics in Obstetrics #2 – Various OB subjects, University of Utah

Clinical Teaching

1993-Present Service Rotation at Intermountain Medical Center, LDS Hospital and University of Utah Hospitals

and Clinics

Small Group Teaching

1997-Present Resident Lecture Series

2006-Present Director, Resident Research Day

PEER-REVIEWED PUBLICATIONS

1. Litzinger MJ, Mouritsen CL, Grover BB, Esplin MS, Abott JR. (1994). Regional differences in the critical period of neurodevelopment in the mouse: implications for neonatal seizures. J Child Neurol, 9(1):77-80.

2. Esplin, Abbott JR, Smart ML, Burroughs AF, Frandsen TC, Litzinger MJ. (1994). Voltage-sensitive calcium channel development in epileptic DBA/2J mice suggests altered presynaptic function. Epilepsia, 35(5),911-4.

3. Esplin MS, Hallam S, Farrington PF, Nelson L, Byrne JLB, Ward KJ. (1998). Myotonic dystrophy is a significant cause of idiopathic polydramnios. Am J Obstet Gynecol, Oct;179(4):974-7.

4. Esplin MS, Branch DSW, Stagaro-Green A. (1998). Thyroid autoantibodies are not associated with recurrent pregnancy loss. Am J Obstet Gynecol, Dec;179(6 part 1):1583-6.

5. Esplin MS, Clark SL. (1999). Ischemic heart disease and myocardial infarction during pregnancy. Contemporary Ob Gyn, Feb.

6. Branch DW, Peaceman AM, Druzin M, Silver RK, El-Sayed Y, Silver RM, Esplin MS, Spinnato J, Harger J. (2000). A multicenter placebo-controlled pilot study of intravenous immune globulin treatment of antiphospholipid syndrome during pregnancy. The Pregnancy Loss Study Group. Am J Obstet Gynecol 182(1 part 1):122-7.

7. Silver RS, Porter TF, Branch DW, Esplin MS, Scott JR. (2000). Neonatal thrombocytopenia: antenatal management. Am J Obstet Gynecol, May;182(5):1233-8.

8. Esplin MS, Fausett MB, Fraser A, Kerber R, Mineau G, Carrillo J, Varner MW. (2001). Paternal and maternal components of the predisposition to preeclampsia. New Eng J Med, Mar:22;344(12):867-72.

9. Fausett MB, Vogtlander M, Lee RM, Esplin MS, Branch DW, Rodgers GM, Silver RM. (2001). Heparin-induced thrombocytopenia is rare in pregnancy. Am J Obstet Gynecol, Jul;185(1), 148-52..

10. Esplin MS, Fausett MB, Faux DS, Graves SW. (2003). Changes in the isoforms of the sodium pump in the placenta and myometrium of women in labor. Am J Obstet Gynecol, Mar;188(3):759-64.

11. Esplin MS, Romero R, Chaiworapongsa T, Kim YM, Edwin S, Gomez R, Gonzalez R, Adashi EY. (2003). Amniotic fluid levels of immunoreactive monocyte chemotactic protein-1 increase during term parturition. J Matern Fetal Neonatal Med, Jul;14(1):51-6.

12. Merrell K, Southwick K, Graves SW, Esplin MS, Lewis NE, Thulin CD. (2004). Analysis of low-abundance, low-molecular-weight serum proteins using mass spectrometry. J Biomol Tech, Dec;15(4):238-48.

13. Ponder R, Esplin M, Silver R, LaCoursiere Y, Byrne J. (2004). Middle cerebral artery peak velocity-accuracy and reliability. Am J Obstet Gynecol, 191(6):S149.

14. Esplin MS, Romero R, Chaiworapongsa T, Kim YM, Edwin S, Gomez R, Mazor M, Adashi EY. (2005). Monocyte chemotactic protein-1 is increased in the amniotic fluid of women who deliver preterm in the presence or absence of intraamniotic infection. J Matern Fetal Neonatal Med, Jun;17(6):365-73.

15. Varner MW, Esplin MS. (2005). Current understanding of genetic factors in preterm birth. BJOG, 112 (suppl 1), 28-31.

16. Esplin MS, Varner MW. (2005). Genetic factors in preterm birth – the future. BJOG, 112 (suppl 1), 97-102.

17. Esplin MS, Peltier MR, Hamblin S, Smith S, Fausett MB, Dildy GA, Branch DW, Silver RM, dashi EY. (2005). Monocyte chemotactic protein-1 expression is increased in human gestational tissues during term and preterm labor. Placenta, Sep-Oct;26(8-9):661-71.

18. Esplin MS, Fausett MB, Peltier MR, Hamblin S, Silver RM, Branch DW, Adashi EY, Whiting D. (2005). The use of cDNA microarray to identify differentially expressed labor-associated genes within the human myometrium during labor. Am J Obstet Gynecol, Aug;193(2):404-13.

19. Esplin MS. (2005). Antiphospholipid syndrome. ACOG Practice Bulletin No. 68. American College of Obstetricians and Gynecologist. Obstet Gynecol, 106:1113-21.

20. Vance CJ, Esplin MS, Hamblin S, Graves SW. (2006). Alterations in uterine sodium pump abundance may contribute to the onset and progression of term and preterm labor in mice. Am J Obstet Gynecol, Nov;195(5):1407-14.

21. Wagner LA, Christensen CJ, Dunn DM, Spangrude GJ, Georgelas A, Kelley LL, Esplin MS, Weiss RB, Gleich GJ. (2007). EGO, A novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression. Blood, Jun;109:5191-8.

22. Holmgren C, Esplin MS, Hamblin S, Molenda M, Simonsen S, Silver R. (2008). Evaluation of the use of anti-TNF-alpha in an LPS-induced murine model. J Reprod Immunol, Jul;78(2):134-9.

23. Esplin MS, O’Brien E, Fraser A, Kerber RA, Clark E, Simonsen SE, Holmgren C, Mineau GP, Varner MW. (2008). Estimating recurrence of spontaneous preterm delivery. Obstet Gynecol, Sep;112(3):516-23.

24. Merrell K, Thulin CD, Esplin MS, Graves SW. (2008). Systematic internal standard selection for capillary liquid chromatography-mass spectrometry time normalization to facilitate serum proteomics. J Biomol Tech, Dec:19(5):320-7.

25. Clark EAS, LaCoursiere DY, Byrne JLB, Ponder R, Silver RM, Esplin MS. (2009). Reliability of fetal middle cerebral artery velocity: a randomized controlled trial of sonographer training. J Ultrasound Med, Jan;28(1):19-25.

26. Peltier MR, Faux DS, Hamblin SD, Cooper C, Silver RM, Esplin MS. (2009). Effect of aspirin treatment on TNFalpha production by women with a history of preterm birth. J Reprod Immunol, Jun;80(1-2):109-14.

27. Manuck TA, Eller LG, Stoddard G, Esplin MS, Varner MV, Silver RM. (2009). Outcomes of expectantly managed preterm premature rupture of membranes occurring less than 24 weeks gestation. Obstet Gynecol, Jul;114(1):29-37.

28. Merrell K, Thulin CD, Esplin MS, Graves SW. (2009). An integrated serum proteomic approach capable of monitoring the low molecular weight proteome with sequencing of intermediate to large peptides. Rapid Commun Mass Spectrom, 23(17), 2685-96.

29. Warren JE, Nelson LM, Stoddard GJ, Esplin MS, Varner MW, Silver RM. (2009). Polymorphisms in the promoter region of the interleukin-10 (IL-10) gene in women with cervical insufficiency. Am J Obstet Gynecol, Oct;201(4):372.e1-5.

30. Peltier MR, Faux DS, Hamblin SD, Silver RM, Esplin MS. (2010). Cytokine production by peripheral blood mononuclear cells of women with a history of preterm birth. J Reprod Immunol, Jan;84(1):111-6.

31. Manuck TA, Major HD, Varner MS, Chettier R, Nelson L, Esplin MS. (2010). Progesterone receptor genotype, family history, and spontaneous preterm birth. Obstet Gynecol, Apr;115(4):765-70.

32. Esplin MS, Merrell K, Goldenberg R, Lai Y, Iams JD, Mercer B, Spong CY, Miodovnik M, Simhan HN, van Dorsten P, Dombrowski M; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. (2011). Proteomic identification of serum peptides predicting subsequent spontaneous preterm birth. Am J Obstet Gynecol, May;294(5):391.

33. Manuck TA, Henry E, Gibson J, Varner MW, Porter TF, Jackson GM, Esplin MS. (2011). Pregnancy outcomes in a recurrent preterm birth prevention clinic. Am J Obstet Gynecol, Apr;204(4):320.

34. Jackson M, Holmgren CM, Esplin MS, Henry E, Varner MW. (2011). Frequency of fetal heart rate categories and short-term neonatal outcome. Obstet Gynecol, Oct;118(4):803-8.

35. Sullivan AE, Hopkins PN, Weng HY, Henry E, Lo JO, Varner MW, Esplin MS. (2012). Delivery of monochorionic twins in the absence of complications: analysis of neonatal outcomes and costs. Am J Obstet Gynecol, Mar;206(3):257.

36. Ma J, Esplin MS, Adair CD, Mason LA, Graves SW. (2012). Increasing evidence for and regulation of a human placental endogenous digitalis-like factor. Reprod Sci, 19(4), 437-48.

37. Holmgren C, Scott JR, Porter TF, Esplin MS, Bardsley T. (2012). Uterine rupture with attempted VBAC, decision to delivery time, and neonatal outcome. Obstet & Gynecol, Apr;119(4):725-31.

38. Grobman WA, Thom EA, Spong CY, Iams JD, Saade GR, Mercer BM, Tita AT, Rouse DJ, Sorokin Y, Wapner RJ, Leveno KJ, Blackwell S, Esplin MS, Tolosa JE, Thorp JM Jr, Caritis SN, Van Dorsten JP; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MJMU) Network. (2012). 17 alpha-hydroxyprogesterone capraoate to prevent prematurity in nulliparas with cervical length less than 30 mm. Am Obstet Gynecol Nov;207(5):390.e1-8.

39. Morisaki N, Esplin MS, Varner MW, Henry E, Oken E. (2013). Declines in birth weight and fetal growth independent of gestational length. Obstet Gynecol, Jan;121(1):51-8.

40. Simonsen S, Lyon J, Stanford J, Porucznik C, Esplin M, Varner M. (2013). Risk factors for recurrent preterm birth in multiparous Utah women: a historical cohort study. BJOG, Feb 19.

41. Metz TD, Stoddard GJ, Henry E, Jackson M, Holmgren C, Esplin S. (2013). How do good candidates for trial of labor after cesarean (TOLAC) who undergo elective repeat cesarean differ from those who choose TOLAC? Am J Obstet Gynecol Feb 12.

42. Holmgren C, Jackson GM, Horne B, Henry E, and Esplin MS. (2013). A risk stratification model to predict adverse neonatal outcome in labor. Journal of Perinatology (accepted for publication 2/12/13).

43. Heuser C, Knight S, Esplin MS, Eller, AG, Holmgren CM, Richards D, Henry E, Jackson M. (2013). Tachysystole in term labor: incidence, risk factors, outcomes, and effect on fetal heart tracings. Am J Obstet and Gynecol, in press (April 2013).

44. Wu W, Clark EA, Stoddard GJ, Watkins WS, Esplin MS, Manuck TA, Xing J, Varner MWV, Jorde LB (2013). Effect of interleukin-6 polymorphism on risk of preterm birth within population strata: a meta-analysis. BMC Genetics Apr 25;14:30.

45. Turok DK, Clark EA, Esplin MS. (2013). Framework for preventing preterm birth must include contraception. Am J Obstet Gynecol. Jun;208(6):508.

46. Manuck TA, Watkins WS, Moore B, Esplin MS, Varner MW, Jackson GM, Yandell M, Jorde L. Pharmacogenomics of 17-alpha hydroxyprogesterone caproate for recurrent preterm birth prevention. Am J Obstet Gynecol. 2014 Apr;210(4):321

47. Sadovsky Y, Esplin MS, Garite TJ, Nelson DM, Parry SI, Saade GR, Socol ML, Spong CY, Varner MW, D'Alton ME. Advancing research transdisciplinarity within our discipline. Am J Obstet Gynecol. 2014 Feb 11

48. Graves SW, Esplin MS, McGee P, Rouse DJ, Leveno KJ, Mercer BM, Iams JD, Wapner RJ, Sorokin Y, Thorp JM, Ramin SM, Malone FD, O'Sullivan MJ, Peaceman AM, Hankins GD, Dudley DJ, Caritis SN; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Association of cord blood digitalis-like factor and necrotizing enterocolitis. Am J Obstet Gynecol. 2014 Apr;210(4):328.

49. Iams JD, Grobman WA, Lozitska A, Spong CY, Saade G, Mercer BM, Tita AT, Rouse DJ, Sorokin Y, Wapner RJ, Leveno KJ, Blackwell SC, Esplin MS, Tolosa JE, Thorp JM, Caritis SN, Van Dorsten PJ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network. Adherence to criteria for transvaginal ultrasound imaging and measurement of cervical length. Am J Obstet Gynecol. 2013 Oct;209(4):365.

50. Manuck TA, Watkins WS, Moore B, Esplin MS, Varner MW, Jackson GM, Yandell M, Jorde L. Pharmacogenomics of 17-alpha hydroxyprogesterone caproate for recurrent preterm birth prevention. Am J Obstet Gynecol. 2014 Apr;210(4):321

51. Parry S, Zhang H, Biggio J, Bukowski R, Varner M, Xu Y, Andrews WW, Saade GR, Esplin MS, Leite R, Ilekis J, Reddy UM, Sadovsky Y, Blair IA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Genomic and Proteomic Network for Preterm Birth Research. Maternal serum serpin B7 is associated with early spontaneous preterm birth. Am J Obstet Gynecol. 2014 Jun 19

52. Grobman WA, Lai Y, Iams JD, Reddy UM, Mercer BM, Saade G, Tita AT, Rouse DJ, Sorokin Y, Wapner RJ, Leveno KJ, Blackwell SC, Esplin MS, Tolosa JE, Thorp JM, Caritis SN; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Prediction of Spontaneous Preterm Birth Among Nulliparous Women With a Short Cervix. J Ultrasound Med. 2016 Jun;35(6):1293-7.

53. Kedia K, Smith SF, Wright AH, Barnes JM, Tolley HD, Esplin MS, Graves SW. Global "omics" evaluation of human placental responses to preeclamptic conditions. Am J Obstet Gynecol. 2016 Mar 10.

54. Hoffman MK, Turan OM, Parker CB, Wapner RJ, Wing DA, Haas DM, Esplin MS, Parry S, Grobman WA, Simhan HN, Myers S, Holder TE Jr, Rumney P, Litton CG, Silver RM, Elovitz MA, Peaceman AM, Emery S, Mercer BM, Koch MA, Saade GR; Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b) Network. Ultrasound Measurement of the Fetal Adrenal Gland as a Predictor of Spontaneous Preterm Birth. Obstet Gynecol. 2016 Apr;127(4):726-34.

55. Anand S, Young S, Esplin MS, Peaden B, Tolley HD, Porter TF, Varner MW, D'Alton ME, Jackson BJ, Graves SW. Detection and confirmation of serum lipid biomarkers for preeclampsia using direct infusion mass spectrometry. J Lipid Res. 2016 Apr;57(4):687-96.

56. Saade GR, Boggess KA, Sullivan SA, Markenson GR, Iams JD, Coonrod DV, Pereira LM, Esplin MS, Cousins LM, Lam GK, Hoffman MK, Severinsen RD, Pugmire T, Flick JS, Fox AC, Lueth AJ, Rust SR, Mazzola E, Hsu C, Dufford MT, Bradford CL, Ichetovkin IE, Fleischer TC, Polpitiya AD, Critchfield GC, Kearney PE, Boniface JJ, Hickok DE. Development and validation of a spontaneous preterm delivery predictor in asymptomatic women. Am J Obstet Gynecol. 2016 May;214(5):633.

57. Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Genomics and Proteomics Network for Preterm Birth Research (GPN-PBR). Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth. Am J Obstet Gynecol. 2016 Mar;214(3):376.

58. Esplin MS, Manuck TA, Varner MW, Christensen B, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J. Cluster analysis of spontaneous preterm birth phenotypes identifies potential associations among preterm birth mechanisms. Am J Obstet Gynecol. 2015 Sep;213(3):429.

59. Wu W, Witherspoon DJ, Fraser A, Clark EA, Rogers A, Stoddard GJ, Manuck TA, Chen K, Esplin MS, Smith KR, Varner MW, Jorde LB. The heritability of gestational age in a two-million member cohort: implications for spontaneous preterm birth. Hum Genet. 2015 Jul;134(7):803-8.

60. Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J; Eunice Kennedy Shriver National Institute of Child Health and Human Development Genomics and Proteomics Network for Preterm Birth Research. The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool. Am J Obstet Gynecol. 2015 Apr;212(4):487.

61. Haas DM, Parker CB, Wing DA, Parry S, Grobman WA, Mercer BM, Simhan HN, Hoffman MK, Silver RM, Wadhwa P, Iams JD, Koch MA, Caritis SN, Wapner RJ, Esplin MS, Elovitz MA, Foroud T, Peaceman AM, Saade GR, Willinger M, Reddy UM; NuMoM2b study. A description of the methods of the Nulliparous Pregnancy Outcomes Study: monitoring mothers-to-be (nuMoM2b). Am J Obstet Gynecol. 2015 Apr;212(4):539.

62. Miller R, Smiley R, Thom EA, Grobman WA, Iams JD, Mercer BM, Saade G, Tita AT, Reddy UM, Rouse DJ, Sorokin Y, Blackwell SC, Esplin MS, Tolosa JE, Caritis SN; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network. The association of beta-2 adrenoceptor genotype with short-cervix mediated preterm birth: a case-control study. BJOG. 2015 Sep;122(10):1387-94.

63. Zhang H, Baldwin DA, Bukowski RK, Parry S, Xu Y, Song C, Andrews WW, Saade GR, Esplin MS, Sadovsky Y, Reddy UM, Ilekis J, Varner M, Biggio JR Jr; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Genomic and Proteomic Network for Preterm Birth Research (GPN-PBR). A genome-wide association study of early spontaneous preterm delivery. Genet Epidemiol. 2015 Mar;39(3):217-26.

64. Romero ST, Holmgren CC, Feltovich H, Porter TF, Esplin MS. Cervical length screening: a randomized trial assessing the impact on visit length and patient attitudes. J Ultrasound Med. 2014 Dec;33(12):2159-63.

64. Carlson LC, Romero ST, Palmeri ML, Muñoz Del Rio A, Esplin SM, Rotemberg VM, Hall TJ, Feltovich H. Changes in shear wave speed pre- and post-induction of labor: a feasibility study. Ultrasound Obstet Gynecol. 2015 Jul;46(1):93-8.

65. Nye KS, Esplin MS, Monson KL. Umbilical cord artery mechanical properties at various gestational ages. Am J Perinatol. 2015 Feb;32(3):263-70.

66. Esplin MS. The Importance of Clinical Phenotype in Understanding and Preventing Spontaneous Preterm Birth. Am J Perinatol. 2016 Feb;33(3):236-44

67. Folsom S, Esplin MS, Edmunds S, Metz TD, Jackson GM, Porter TF, Varner MW. Patient Counseling and Preferences for Elective Repeat Cesarean Delivery. AJP Rep. 2016 Apr;6(2):e226-31

68. Theilen LH, Fraser A, Hollingshaus MS, Schliep KC, Varner MW, Smith KR, Esplin MS. All-Cause and Cause-Specific Mortality After Hypertensive Disease of Pregnancy. Obstet Gynecol. 2016 Aug;128(2):238-44

69. Grobman WA, Parker C, Wadhwa PD, Willinger M, Simhan H, Silver B, Wapner RJ, Parry S, Mercer B, Haas D, Peaceman AM, Hunter S, Wing D, Caritis S, Esplin S, Hoffman M, Ludmir J, Iams J, Long E, Saade G, Reddy UM; Eunice Kennedy Shriver National Institute of Child Health Human Development nuMoM2b Network, Bethesda, MD. Racial/Ethnic Disparities in Measures of Self-reported Psychosocial States and Traits during Pregnancy. Am J Perinatol. 2016 Dec;33(14):1426-1432

70. Tita AT, Szychowski JM, Boggess K, Saade G, Longo S, Clark E, Esplin S, Cleary K, Wapner R, Letson K, Owens M, Abramovici A, Ambalavanan N, Cutter G, Andrews W; C/SOAP Trial Consortium. Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. N Engl J Med. 2016 Sep 29;375(13):1231-41

71. Monson MA, Gibbons KJ, Esplin MS, Varner MW, Manuck TA. Pregnancy Outcomes in Women With a History of Previable, Preterm Prelabor Rupture of Membranes. Obstet Gynecol. 2016 Nov;128(5):976-982

72. Manuck TA, Stoddard GJ, Fry RC, Esplin MS, Varner MW. Nonresponse to 17-alpha hydroxyprogesterone caproate for recurrent spontaneous preterm birth prevention: clinical prediction and generation of a risk scoring system. Am J Obstet Gynecol. 2016 Nov;215(5):622

73. Theilen LH, Varner MW, Smith KR, Esplin MS. In Reply. Obstet Gynecol. 2016 Dec;128(6):1446.

74. Manuck TA, Watkins WS, Esplin MS, Biggio J, Bukowski R, Parry S, Zhan H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J, Yandell M, Varner MW, Jorde LB; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Genomics and Proteomics Network for Preterm Birth Research (GPN-PBR). Pharmacogenomics of 17-alpha hydroxyprogesterone caproate for recurrent preterm birth: a case-control study. BJOG. 2017 Jan 31

75. Boggess KA, Tita A, Jauk V, Saade G, Longo S, Clark EA, Esplin S, Cleary K, Wapner R, Letson K, Owens M, Blackwell S, Beamon C, Szychowski JM, Andrews W; Cesarean Section Optimal Antibiotic Prophylaxis Trial Consortium. Risk Factors for Postcesarean Maternal Infection in a Trial of Extended-Spectrum Antibiotic Prophylaxis. Obstet Gynecol. 2017 Mar;129(3):481-485

76. Esplin MS, Elovitz MA, Iams JD, Parker CB, Wapner RJ, Grobman WA, Simhan HN, Wing DA, Haas DM, Silver RM, Hoffman MK, Peaceman AM, Caritis SN, Parry S, Wadhwa P, Foroud T, Mercer BM, Hunter SM, Saade GR, Reddy UM; nuMoM2b Network. Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women. JAMA. 2017 Mar 14;317(10):1047-1056

77. Bodnar LM, Simhan HN, Parker CB, Meier H, Mercer BM, Grobman WA, Haas DM, Wing DA, Hoffman MK, Parry S, Silver RM, Saade GR, Wapner R, Iams JD, Wadhwa PD, Elovitz M, Peaceman AM, Esplin S, Barnes S, Reddy UM. Racial or Ethnic and Socioeconomic Inequalities in Adherence to National Dietary Guidance in a Large Cohort of US Pregnant Women. J Acad Nutr Diet. 2017 Mar 14

78. Metz TD, Gonzalez C, Allshouse AA, Henry E, Esplin S. Influence of Patient-Level Factors on Mode of Delivery among Operative Vaginal Delivery Candidates in Modern Practice. Am J Perinatol. 2017 Apr 4. doi: 10.1055/s-0037-1601441.

79. Radek Bukowski , Yoel Sadovsky, Hani Goodarzi, Heping Zhang, Joseph R. Biggio, Michael Varner, Samuel Parry, Feifei Xiao, Sean M. Esplin, William Andrews, George R. Saade, John V. Ilekis, Uma M. Reddy, Donald A. Baldwin, Eunice Kennedy Shriver National Institute of Child Health and Human Development Genomic and Proteomic Network for Preterm Birth Research. Onset of human preterm and term birth is related to unique inflammatory transcriptome profiles at the maternal fetal interface. PeerJ. 2017 Sept 1.

80. Richards DS, Wong LF, Esplin MS, Collingridge DS. Anticipatory Corticosteroid Administration to Asymptomatic Women with a Short Cervix. Am J Perinatol. 2018 Mar;35(4):397-404.

81. Haas DM, Marsh DJ, Dang DT, Parker CB, Wing DA, Simhan HN, Grobman WA, Mercer BM, Silver RM, Hoffman MK, Parry S, Iams JD, Caritis SN, Wapner RJ, Esplin MS, Elovitz MA, Peaceman AM, Chung J, Saade GR, Reddy UM. Prescription and Other Medication Use in Pregnancy. Obstet Gynecol. 2018 May;131(5):789-798.

82. Theilen LH, Meeks H, Fraser A, Esplin MS, Smith KR, Varner MW. Long-term mortality risk and life expectancy following recurrent hypertensive disease of pregnancy. Am J Obstet Gynecol. 2018 Jul;219(1):107.e1-107.

83. Knighton AJ, Grissom CK, Knowlton KU, Sean Esplin M, Graydon T, Srivastava R; Intermountain Healthcare Research Guidance Council. How Community-Based Health Systems Can Embrace Research in the Fee-for-Value Era. Qual Manag Health Care. 2018 Jul/Sep;27(3):180-182.

84. La Rosa M, Jauk V, Saade G, Boggess K, Longo S, Clark EAS, Esplin S, Cleary K, Wapner R, Letson K, Owens MY, Blackwell S, Szychowski JM, Andrews WW, Tita AT; Cesarean Section Optimal Antibiotic Prophylaxis Trial Consortium. Institutional Protocols for Vaginal Preparation With Antiseptic Solution and Surgical Site Infection Rate in Women Undergoing Cesarean Delivery During Labor. Obstet Gynecol. 2018 Aug;132(2):371-376.

85. Bushman ET, Theilen LH, Monson M, Hammad I, Esplin I, Esplin MS. Effect of blood contamination on amniotic fluid detection in vitro using immunoassays. J Matern Fetal Neonatal Med. 2019 Jan 7:1-4.

86. Grobman WA, Rice MM, Reddy UM, Tita ATN, Silver RM, Mallett G, Hill K, Thom EA, El-Sayed YY, Perez-Delboy A, Rouse DJ, Saade GR, Boggess KA, Chauhan SP, Iams JD, Chien EK, Casey BM, Gibbs RS, Srinivas SK, Swamy GK, Simhan HN, Macones GA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network. Labor Induction versus Expectant Management in Low-Risk Nulliparous Women. N Engl J Med. 2018 Aug 9;379(6):513-523.

87. M. Sean Esplin, Mathew K. Hoffman, Lauren Theilen & Peter Kupchak. Prospective evaluation of the efficacy of immunoassays in the diagnosis of rupture of the membranes. The Journal of Maternal-Fetal & Neonatal Medicine. 13 Jan 2019

88. Bushman ET, Theilen LH, Monson M, Hammad I, Esplin I, Esplin MS. Effect of blood contamination on amniotic fluid detection in vitro using immunoassays. J Matern Fetal Neonatal Med. 2019 Jan 7:1-4

89. Ausbeck EB, Jauk VC, Boggess KA, Saade GR, Longo S, Clark EAS, Esplin S, Cleary K, Wapner R, Letson K, Owens M, Abramovici A, Ambalavanan N, Szychowski JM, Andrews W, Tita ATN; Cesarean Section Optimal Antibiotic Prophylaxis Trial Consortium. Impact of Azithromycin-Based Extended-Spectrum Antibiotic Prophylaxis on Noninfectious Cesarean Wound Complications. Am J Perinatol. 2019 Jul;36(9):886-890.

90. La Rosa M, Jauk V, Saade GR, Boggess K, Longo S, Clark EAS, Esplin S, Cleary K, Wapner R, Letson K, Owens MY, Blackwell S, Szychowski JM, Andrews W, Tita AT; Cesarean Section Optimal Antibiotic Prophylaxis Trial Consortium. Incidence and Risk Factors for Hospital Readmission or Unexpected Visits in Women Undergoing Unscheduled Cesarean Delivery. Am J Perinatol. 2019 Sep;36(11):1115-1119

91. Hammad IA, Meeks H, Fraser A, Theilen LH, Esplin MS, Smith KR, Varner MW. Risks of cause-specific mortality in offspring of pregnancies complicated by hypertensive disease of pregnancy. Am J Obstet Gynecol. 2019 Jul 20

92. Bilder DA, Esplin MS, Coon H, Burghardt P, Clark EAS, Fraser A, Smith KR, Worsham W, Chappelle K, Rayner T, Bakian AV. Early Second Trimester Maternal Serum Steroid-Related Biomarkers Associated with Autism Spectrum Disorder. J Autism Dev Disord. 2019 Aug 13

93. Bahr TM, DuPont TL, Morris DS, Pierson SE, Esplin MS, Brown SM, O'Brien EA, Ilstrup SJ, Christensen RD. First report of using low-titer cold-stored type O whole blood in massive postpartum hemorrhage. Transfusion. 2019 Oct;59(10):3089-3092.

NON PEER-REVIEWED JOURNAL ARTICLES

REVIEW ARTICLES

1. Esplin MS, Varner MW. (1997). Progression of pulmonary arteriovenous malformation during pregnancy: case report and review of the literature. Obstet Gynecol Surv Apr;52(4):248-53. Review.

2. Esplin MS, Branch DW. (1997). Immunosuppressive drugs and pregnancy. Obstet Gynecol Clin North Am, Sep;24(3):601-16. Review.

3. Esplin MS, Clark SL. (1998). Outpatient management of asthma during pregnancy. Clin Obstet Gynecol Sep;41(3):555-63. Review.

4. Esplin MS, Branch DW. (1999). Diagnosis and management of thrombotic microangiopathies during pregnancy. Clin Obstet Gynecol Jun;42(2):369-7. Review.

5. Esplin MS. (2001). Management of antiphospholipid syndrome during pregnancy. Clin Obstet Gynecol, Mar;44(1):20-8. Review.

6. Tavares AB, Esplin MS, Adashi EY. (2001). Differential hybridization and other strategies to identify novel ovarian genes. Semin Reprod Med, Jun;19(2):167-73. Review.

7. Esplin MS. (2006). Preterm birth: a review of genetic factors and future directions for genetic study. Obstet Gynecol Surv, Dec;61(12):800-6.

8. Clark EAS, Esplin S, Torres L, Turok D, Yoder B, Varner MW, Winger S. (2013). Prevention of recurrent preterm birth: role of the neonatal follow-up program. Maternal Child Health Journal, in press.

9. Esplin MS. Overview of spontaneous preterm birth: a complex and multifactorial phenotype. Clin Obstet Gynecol. 2014 Sep;57(3):518-30.

10. M. Sean Esplin, MD ; Alexandra G. Eller, MD, MPH. 10 tips for overcoming common challenges of intrapartum fetal monitoring. OBG Manag. 2016 May;28(5):34–36,38–42,44–46

OTHER (Commentary / Letters / Editorials / Case Reports / Video/Film)

Case Reports

1. Turok DK, Gurtcheff SE, Esplin MS, Shah M, Simonsen SE, Trauscht-Van Horn J, Silver RM. (2008). Second trimester termination of pregnancy: a review by site and procedure type. Contraception,

Mar;77:155-61.

Letters

1. Turok DK, Clark EA, Esplin MS. (2013). Framework for preventing preterm birth must include

contraception. Letter to the Editor. Am J Obstet, Jan 23.

Other

1. Esplin MS. Circumcision. (1997), Encyclopedia of Reproduction.

ABSTRACTS AND PRESENTATIONS

1. Esplin MS, Silver RM, Branch DW, Stagnaro-Green A. Thyroid autoantibodies are not associated with recurrent pregnancy loss. American Thyroid Association. 1997.

2. Porter TF, Clark SC, Esplin MS, Took-Miller C, and Scott JR. Timing of Delivery and neonatal outcome in patients with clinically overt uterine rupture during VBAC. Society of Perinatal Obstetricians, 1998.

3. Esplin MS, Branch DW. IVIG treatment does not improve pregnancy outcomes in patients with antiphospholipid syndrome. 8th International Symposium on Antiphospholipid Antibodies, 1998.

4. Madden S, Nelson L, Esplin MS, Dizon-Townson DS, Ward KJ. Polymease chain reaction to detect subclinical infection in preterm neonates. Society for Maternal Fetal Medicine, 1999.

5. Fausett MB, Nelson L, Esplin MS, Metherall JM, Ward KJ. Fatty acid binding protein2 is not associated with pre-eclampsia. Society for Maternal Fetal Medicine, 1999.

6. Esplin MS, Silver RM, Branch DW, Stagnaro-Green A. Thyroid autoantibodies are not associated with an increased risk of future pregnancy loss in women with a history of recurrent pregnancy loss. Society for Gynecologic Investigators, 1999.

7. Esplin MS, IVIG treatment does not improve pregnancy outcomes in patients with antiphospholipid syndrome. The recurrent pregnancy loss group. Annual Meeting of the Society for Gynecologic Investigation. 1999.

8. Fausett MB, Esplin MS, Oshiro BT, Yoder B, Groden MC, Higby K. Indomethascin therapy for preterm labor prolongs gestation and is not associated with increased neonatal complications in infants delivered prior to 32 weeks. Society for Maternal Fetal Medicine, 2000.

9. Fausett MB, Esplin MS, Sitarz B, Smith SB, Oshiro BT, Porter TF, Varner MW. Ictraamniotic infection does not affect long-term cognitive of psychomotor development in very low birth weight infants. Society for Maternal Fetal Medicine, 2000.

10. Fausett MB, Esplin MS, Oshiro BT, Yoder B, Gordon MC, Higby K. Antenatal steroid therapy in women who later develop intaamniotic infection is not associated with an increased risk of infection in preterm neonates. Society for Maternal Fetal Medicine, 2000.

11. Esplin MS, Fausett MB, Porter TF, Branch DW, Oshiro BT, Smith SB, Varner MW. Long term effects of repeated courses of antenatal steroids. NIH Consensus conference on repeated doses of antenatal steroids, NIH Bethesda, MD. 2000

12. Graves S, Esplin MS, Fausett MB, Faux D. Reductions in the alph 3 isoform of the sodium pump in term placenta may induce hormonal secretion that mediates active labor. Society for Maternal Fetal Medicine, 2002.

13. Esplin MS, Chaiworapongsa T, Kim YM, Edwin S, Adashi EY. Monocyte chemotactic protein-I is increased in the amniotic fluid of patient with preterm delivery in the presence or absence of intra-amniotic infection. Society for Maternal Fetal Medicine, 2002.

14. Esplin MS, Frias AE, Peltier MR, Faux D, Peterson T, Hamblin S, Smith S, Silver RM. Aspirin differentially modulates cytokine production by peripheral blood mononuclear leukocytes in women with a history of premature delivery. Society for Maternal Fetal Medicine, 2002.

15. Esplin MS, Peltier MR, Lewandowski MS, Hamblin S, Smith S, Silver RM, Adashi EY. Monocyte Esplin MS, Chaiworapongsa T, Kim YM, Edwin S, Adashi EY, Romero R. Amniotic fluid levels of monocyte chemotactic protein-1 increasing during term parturition. Society for Maternal Fetal Medicine, 2002.

16. Esplin MS, Hamblin S, Smith S, Peltier MR, Silver RM, Adashi EY. Monocyte chemotactic protein-1 levels increase in the mymetrium and membranes during labor and after stimulation with cytokines. Society for Genycologic Investigation, 2003.

17. Esplin MS, Hamblin S, Smith S, Frias AE, Peltier MR, Silver RM, Adashi EY. MCP-1 expression is increased following LPS-induced preterm labor and preterm delivery is delayed in the MCP-1 Null-Mutant. Society for Gynecologic Investigation, 2003.

18. Frias AE, Esplin MS, Hamblin S, Smith S, English J, Peltier MR, Silver RM, Adashi EY. The use of CDNA microarray to identify and characterize the time course and patterns of gene expression over the final third of gestation and during spontaneous labor. Society for Maternal Fetal Medicine, 2004.

19. Esplin MS, Thulin CD, Southwick K, Silver RM, Varner MW, Whiting D, Graves SW. The use of proteomic analysis for the discrimination of term and preterm labor. Society for Maternal Fetal Medicine, 2004.

20. Clark E, Esplin MS, Fraser A, O’Brien E, Mineau G, Varner MW. The risk of recurrent preterm birth is significantly higher in patients with a previous history of very early premature delivery. Society for Maternal Fetal Medicine, 2004.

21. Cooper C, Esplin MS, Peltier MR, Faux D, Smith S, Silver RM, Varner MW, Southwick K. TNF-alpha production in whole blood and peripheral blood mononuclear leukocytes before and after aspirin therapy in patients with a history of preterm delivery. Society for Maternal Fetal Medicine, 2004.

22. Thulin CD, Esplin MS, Graves SW, Frias AE, Silver RM, Varner MW, Southwick K. Proteomics and mechanistic candidates of term and preterm labor. Society for Maternal Fetal Medicine, 2004.

23. Clark E, Esplin MS, Fraser A, O’Brien E, Mineau G, Varner MW. Factors associated with preterm birth differ depending on the degree of prematurity at the time of delivery. Society for Maternal Fetal Medicine, 2004.

24. Thulin CD, Esplin MS, Graves SE, Whiting DG, Southwick K, Silver RM, Varner MW. The use of proteomic analysis for the discrimination of an identification of mechanistic candidates of preeclampsia at term. Society for Gynecologic Investigation, 2004.

25. Clark E, Esplin MS, Fraser A, O’Brien E, Mineau G, Varner MW. Predicting spontaneous preterm birth: risk factors and recurrence rates. Society for Gynecologic Investigation, 2004.

26. Peltier MR, Barney BM, Freeman AJ, Esplin MS, Silver RM. Acetaminophen inhibits lipopolysaccharide-induced pge 2 production by fetal brains. Society for Gynecologic Investigation Los Angeles, California. 2005

27. Holmgren C, Aagaard K, Frias A, Esplin MS, Silver R. Differential expression of angiogenic factors and cytokines among pregnancies complicated by IUGR and severe preeclampsia. Society for Gynecologic Investigation; Los Angeles, California. 2005.

28. Warren JE, Silver RM, Sandoval C, Nelson L, Esplin MS, Porter TF, Branch DW, Varner MW. Cervical insufficiency: a genetic condition? Collagen 1α1 intron 1 SP1 and Transforming Growth Factor β Arg-25-Pro polymorphisms in women with cervical insufficiency. Society for Gynecologic Investigation 52nd Annual Meeting; 2005.

29. Warren J, Silver RM, Dalton J, Paegle R, Nelson K, Nelson L, Esplin MS, Varner M. Tumor necrosis factor alpha 308 (GàA) polymorphism in women with cervical insufficiency. Society for Gynecologic Investigation 53rd Annual Scientific Meeting; Ontario, Canada 2006.

30. Manuck TA, Martinez-Borges A, Mertz HL. Does ethnicity influence response to tocolytics. Poster presentation. Society for Gynecologic Investigation 54th Annual Scientific Meeting 2007, Reno, NV.

31. Warren J, Silver RM, Dalton J, Nelson L, Nelson K, Esplin MS, Varner M. Nuclear factor κB1 (NF-κB1) and matrix metalloproteinase 9 (MMP9) polymorphisms in women with cervical insufficiency. Society for Maternal Fetal Medicine 27th Annual Scientific Meeting; San Francisco, California 2007.

32. Manuck TA, Eller AG, Esplin MS, Silver RM. Outcomes following expectant management of previable preterm premature rupture of membranes. Society for Gynecologic Investigation 55th Annual Scientific Meeting 2008, San Diego, CA.

33. Clark EAS, Simonsen SE, Rose NC, Silver RM, Esplin MS. The effect of standardized fetal middle cerebral artery Doppler ultrasound training protocol on sonographer skill development and self-assessment. Abstract accepted for presentation at the CAOG Meeting, October 2009.

34. Major H, Manuck T, Nelson L, Chettier R, Holmgren C, Esplin MS. Polymorphisms of vascular and inflammatory genes are associated with family history of spontaneous preterm birth. Society for Gynecologic Investigation 56th Annual Scientific Meeting 2009, Glasgow, Scotland.

35. Major H, Manuck T, Nelson L, Chettier R, Holmgren C, Esplin MS. The role of fetal inflammatory response in familial spontaneous preterm birth. Society for Gynecologic Investigation 56th Annual Scientific Meeting 2009, Glasgow, Scotland.

36. Major H, Manuck T, Nelson L, Chettier R, Holmgren C, Esplin MS. The role of cytokine polymorphisms in recurrent spontaneous preterm birth. Society for Gynecologic Investigation 56th Annual Scientific Meeting 2009, Glasgow, Scotland.

37. Major H, Manuck T, Nelson L, Chettier R, Holmgren C, Esplin MS. Genetic variation in P-selectin is associated with recurrent and inflammatory spontaneous preterm birth. Society for Gynecologic Investigation 56th Annual Scientific Meeting 2009, Glasgow, Scotland.

38. Manuck T, Major H, Nelson L, Chettier R, Varner M, Esplin S. Variation in the progesterone receptor gene occurs more frequently in women at very high risk for spontaneous preterm birth. Society for Gynecologic Investigation 56th Annual Scientific Meeting 2009, Glasgow, Scotland.

39. Manuck T, Major H, Nelson L, Chettier R, Varner M, Esplin S. Family history of preterm birth, progesterone receptor polymorphisms, and subsequent pregnancy outcome. Society for Gynecologic Investigation 56th Annual Scientific Meeting 2009, Glasgow, Scotland.

40. Manuck T, Major H, Nelson L, Chettier R, Esplin S, Varner M. An uncommon haplotype in the progesterone receptor gene is associated with a significantly higher risk of spontaneous preterm birth. Society for Gynecologic Investigation 56th Annual Scientific Meeting 2009, Glasgow, Scotland.

41. Milan K, Manuck TA, Henry E, Esplin S, Holmgren C. Maternal characteristics and fetal outcomes for category I intrapartum fetal heart rate tracing. Society for Maternal Fetal Medicine 30th Annual Meeting 2010, Chicago, IL.

42. Manuck T, Henry E, Jackson M, Varner M, Esplin S. The effect of uterine tachysystole (TS) on interpartum fetal heart rate tracings (FHRTs). Oral concurrent session, Society for Maternal Fetal Medicine 30th Annual Meeting 2010, Chicago, IL.

43. Jackson M, Holmgren C, Esplin M, Henry E, Varner M. Distribution of fetal heart rate (FHR) categories in term labor. Society for Maternal Fetal Medicine 30th Annual Meeting 2010, Chicago, IL.

44. Holmgren C, Esplin MS, Porter TF. Fetal heart rate tracing (FHRT) characteristics associated with category II and neonatal outcomes. Poster session. Society for Maternal Fetal Medicine 30th Annual Meeting 2010, Chicago, IL.

45. Denney J, Holmgren C, Henry E, Rose N, Jackson M, Esplin S. Category III fetal heart rate tracings: a rare occurrence strongly associated with adverse neonatal outcome. Poster session. Society for Maternal Fetal Medicine 30th Annual Meeting 2010, Chicago, IL.

46. Denney J, Holmgren C, Henry E, Rose N, Jackson M, Esplin MS. Category III fetal heart rate tracings: a rare occurrence strongly associated with adverse neonatal outcome. Society for Maternal Fetal Medicine 30th Annual Meeting, 2010, Chicago, IL.

47. Manuck T, Esplin S, Silver R, Varner M. Are babies delivered following early preterm premature rupture of membranes (EPPROM) at higher risk for neonatal morbidity and mortality compared with infants delivered following spontaneous preterm birth (SPTB) with intact membranes? Poster. Society for Gynecologic Investigation 57th Annual Scientific Meeting 2010, Orlando, FL.

48. Milan K, Henry E, Weng H, Esplin S. The nulliparous contribution to preterm birth. Poster. Society for Gynecologic Investigation 57th Annual Scientific Meeting 2010, Orlando, FL.

49. Milan K, Henry E, Hopkins P, Esplin S. Risk factors for spontaneous preterm birth in nulliparous women. Poster. Society for Gynecologic Investigation 57th Annual Scientific Meeting 2010, Orlando, FL.

50. Milan K, Henry E, Hopkins P, Esplin S. The effect of pre-pregnancy maternal body habitus on spontaneous preterm birth in nulliparous patients. Poster. Society for Gynecologic Investigation 57th Annual Scientific Meeting 2010, Orlando, FL.

51. Manuck TA, Major HD, Chettier R, Nelson L, Esplin MS, Varner MV. Fetal progesterone receptor genotype and preterm birth. Poster. Society for Gynecologic Investigation 57th Annual Scientific Meeting 2010, Orlando, FL.

52. Jackson M, Holmgren C, Esplin MS, Henry E, Varner MW. Fetal heart rate category differences between tertiary and community hospitals. Poster. Society for Gynecologic Investigation 57th Annual Scientific Meeting 2010, Orlando, FL.

53. Jackson M, Esplin MS, Henry E, Holmgren CM, Varner MW. Outcomes related to the time in category I and category II FHR patterns in the last 2 hours of term labor. Society for Gynecologic Investigation 57th Annual Scientific Meeting 2010, Orlando, FL.

54. Jackson M, Esplin MS, Holmgren CM, Henry E, Varner MW. Distribution of fetal heart rate category time in the last two hours of labor is related to adverse outcome. Society for Gynecologic Investigation 57th Annual Scientific Meeting 2010, Orlando, FL.

55. Milan T, Henry E, Stoddard G, Yoder B, Milan K, Esplin S. Cesarean section is associated with increased respiratory morbidity in preterm neonates. Poster. Society for Maternal Fetal Mecidine 31st Annual Meeting 2011, San Francisco, CA.

56. Manuck T, Korgenski K, Henry E, Esplin S, Silver B, Varner MW. Rates of neonatal morbidity and mortality following preterm premature rupture of membranes (PPROM) by gestational age at rupture vs. gestational age at delivery. Poster. Society for Maternal Fetal Mecidine 31st Annual Meeting 2011, San Francisco, CA.

57. Manuck T, Henry E, Gibson J, Varner M, Porter F, Esplin S. Effect of preterm birth prevention clinic on pregnancy outcomes among women at high risk for recurrent spontaneous preterm birth. Oral presentation. Society for Maternal Fetal Medicine 31st Annual Meeting 2011, San Francisco, CA.

58. Holmgren C, Jackson GM, Esplin MS, Henry E, Horne B. A risk stratification model, including fetal heart rate categorization, to predict intrapartum hypoxia. Oral presentation. Society for Maternal Fetal Mecidine 31st Annual Meeting 2011, San Francisco, CA.

59. Esplin MS. Variation of predictive preterm birth biomarkers obtained by maternal serum proteomics tracking. Oral presentation. Society for Maternal Fetal Medicine 31st Annual Meeting 2011, San Francisco, CA.

60. Lo J, Milan K, Henry E, Hsin-Yi C, Weng MS, Hopkins P, Esplin S. The cost of prematurity: the association between gestational age at delivery and overall neonatal cost. Poster. Society for Gynecologic Investigation 58th Annual Scientific Meeting 2011, Miami, FL.

61. Milan K, Weng HY, Hopkins P, Henry E, Esplin S. The impact of intrauterine growth restriction on neonatal hospital costs. Poster. Society for Gynecologic Investigation 58th Annual Scientific Meeting 2011, Miami, FL.

62. Manuck T, Yi J, Varner M, Holmgren C, Esplin S. Rate of cervical length change and the prediction of recurrent preterm birth. Oral presentation. Society for Gynecologic Investigation 58th Annual Scientific Meeting 2011, Miami, FL.

63. Haakenson C, Holmgren C, Stoddard G, Rose N, Esplin S. The effects of prescription narcotic use during pregnancy. Society for Gynecologic Investigation Annual Meeting 2011, Miami, Florida. USA.

64. Jackson GM, Donnenfeld S, Holmgren CM, Henry E, Esplin MS. Distribution of fetal heart rate (FHR) categories prior to preterm delivery. Society for Maternal Fetal Medicine 32nd Annual Meeting 2012, Dallas, TX.

65. Heuser C, Esplin MS, Eller A, Holmgren C, Richards D, Knight S, Jackson GM. Incidence and risk factors for tachysystole in term laboring patients. Society for Maternal Fetal Medicine 32nd Annual Meeting 2012, Dallas, TX.

66. Heuser C, Esplin MS, Eller A, Holmgren C, Richards D, Knight S, Jackson GM. Outcomes associated with tachysystole term laboring patients. Society for Maternal Fetal Medicine 32nd Annual Meeting 2012, Dallas, TX.

67. Chin J, Esplin MS, Varner M, Silver B. Changes in maternal lipids from the 2nd to 3rd trimester differ by maternal pre-pregnancy BMI. Society for Maternal Fetal Medicine 32nd Annual Meeting 2012, Dallas, TX.

68. Health NB, Esplin MS, Henry E, Weng C, Varner MW. Trends in severe obstetric morbidity. Society for Maternal Fetal Medicine 32nd Annual Meeting 2012, Dallas, TX.

69. Zhang H, Baldwin DA, Zu Y, Varner MW, Bukowski RK,Parry S, Esplin MS, Andrews WW, Saade GR, Guo X, Sadovsky Y, Ilekis JV, Reddy UM, Biggio JR for the Genomics and Proteomics Network for Preterm Birth Prevention. Society for Gynecologic Investigation Annual Meeting 2012, San Diego, CA.

70. Metz TD, Stoddard GJ, Henry E, Jackson M, Holmgren C, Esplin S. How do good candidates for TOLAC who choose elective repeat cesarean differ from those who choose TOLAC? Society for Gynecologic Investigation Annual Meeting 2012, San Diego, CA.

71. Metz TD, Stoddard G, Henry E, Jackson M, Holmgren C, Esplin S. A simple VBAC prediction model for use at the time of admission. Society for Gynecologic Investigation Annual Meeting 2012, San Diego, CA.

72. Manuck T, Esplin S, Varner M, Jackson M. The contribution of genetic variation within regulatory genes to spontaneous preterm birth. Society for Gynecologic Investigation Annual Meeting 2012, San Diego, CA.

73. Heuser C, Eller L, Holmgren C, Jackson M, Esplin S, Henry E, Knight S. Effects of tachysystole on fetal heart rate tracings. Society for Gynecologic Investigation Annual Meeting 2012, San Diego, CA.

74. Jackson M, Holmgren CM, Esplin MS, Henry E, Varner MW. Time in category II does not correlate with newborn pH in late preterm birth. Society for Maternal Fetal Medicine 32nd Annual Meeting 2012, Dallas, TX.

75. Manuck T, Watkins S, Esplin S, Jackson M, Jorde L, Varner M. Next generation sequencing identifies the IL-12 receptor beta gene as a potential mediator in the response to 17-alpha-hydroxyprogesterone caproate for the prevention of recurrent prematurity. Society for Maternal Fetal Medicine 33rd Annual Meeting 2013, San Francisco, CA.

76. Manuck T, Kamyar M, Esplin S, Porter F, Silver B, Varner M. Cervical cerclage, progesterone supplementation, and spontaneous preterm birth. Society for Maternal Fetal Medicine 33rd Annual Meeting 2013, San Francisco, CA.

77. Kamyar M, Manuck T, Silver RM, Esplin MS, Porter TF, Varner MW. Ultrasonographic cervical length parameters and risk of spontaneous preterm birth<34 weeks after cervical cerclage placement. Society for Maternal Fetal Medicine 33rd Annual Meeting 2013, San Francisco, CA.

78. Parry S, Zhang H, Biggio J, Bukowski R, Varner M, Blair I, Andrews W, Saade G, Esplin S, Ilekis J, Reddy U, Sadovsky Y, for the NICHD Genomic and Proteomic Network for Preterm Birth Research. A multi-center study using proteomics techniques to identify maternal-serum biomarkers for spontaneous preterm delivery. Society for Gynecologic Investigation Annual Meeting 2013, Orlando, FL.

ORAL PRESENTATIONS

Meeting Presentations (Not published abstracts and Not unpublished posters)

National

March 1998 IVIG treatment does not improve pregnancy outcomes in patients with antiphospholipid syndrome, the recurrent pregnancy loss group

Annual Meeting of the Society for Gynecologic Investigation , Atlanta, GA

January 1999 Esplin MS, Fraser A, Kerber R, Mineau G, Carrillo J, Varner MW. Intergenerational paternal predisposition to preeclampsia.

Annual Meeting of the Society for Maternal Fetal Medicine, San Francisco, CA

February 2000 Esplin MS, Fausett MB, Porter TF, Branch DW, Oshiro BT, Smith SB, Varner MW. Multiple courses of antenatal steroids are associated with psychomotor and cognitive developmental delay in infants with a birth weight < 1,500 grams

Annual Meeting of the Society for Maternal Fetal Medicine, Miami, FL

March 2000 Esplin MS, Hennebold J, Adashi EA. The labor gene cascade: critical determinants of term and preterm labor

Annual Meeting of the Society of Gynecologic Investigation, Chicago, IL

2000 Esplin MS, Fausett MB, Porter TF, Branch DW, Oshiro BT, Smith SB, Varner MW.

Long term effects of repeated courses of antenatal steroids

NIH Consensus conference on repeated doses of antenatal steroids, NIH Bethesda, MD

February 2001 Esplin MS, Hamblin S, Fausett MB, Silver RM, Branch DW, Adashi EY. Monocyte

chemotactic protein-I expression is increased in spontaneous term and preterm labor

Annual Meeting of the Society for Maternal Fetal Medicine, Reno, NV

November 2005 Recent Advances in the Prevention of Preterm Birth: An Evidence Based Approach to the

Management of Preterm Labor

March of Dimes Prematurity Awareness Conference, Minneapolis, MN

February 2006 How Will Bioinformatics Change Maternal-Fetal Medicine

Annual Meeting of the Society for Maternal Fetal Medicine, Miami Beach, FL

Local / Regional

February 2003 Advances in Diagnosis and Treatment of Preterm Labor

University of Utah 44th Annual Ob/Gyn Update, Park City, UT

February 2004 New Concepts in Managing Diabetic Pregnancies

University of Utah 45th Annual Ob/Gyn Update, Park City, UT

February 2005 17a-Hydroxyprogesterone for Preterm Labor: The 2005 Perspective

University of Utah 46th Annual Ob/Gyn Update, Park City, UT

September 2005 PPROM

Women & Newborns Outreach Conference, Park City, UT

February 2006 Preterm Labor – Can Evidence-based Medicine Meet the Needs of Clinical Medicine?

University of Utah 47th Annual Ob/Gyn Update, Park City, UT

February 2007 What’s New with PROM

University of Utah 48th Annual Ob/Gyn Update, Park City, UT

May 2007 Advances in the Diagnosis and Management of Preterm Labor

Medcyt CME Dinner Lecture, Salt Lake City, UT

August 2007 Preterm Birth and 17-Ott

Utah Academy of Family Physicians Annual Silver Summit, Park City, UT

December 2007 The Genetics of Pre-Term Birth: From the Utah Perspective

ACOG Utah Section Annual Holiday Meeting, Salt Lake City, UT

February 2008 Multiple Gestations: New Management Paradigms

University of Utah 49th Annual Ob/Gyn Update, Park City, UT

October 2008 Update on Causes of Preterm Labor

Society for Pediatric Pathology, Salt Lake City, UT

2008 Pre-Eclampsia: Overview of Etiologies, Prediction, and Prevention

ARUP noon seminar series, Salt Lake City, UT

February 2009 Fetal Heart Rate Tracing Nomenclature: New Thoughts

University of Utah 50th Annual Ob/Gyn Update, Park City, UT

February 2010 Management and Prevention of OB Catastrophes

University of Utah 51st Annual Ob/Gyn Update, Park City, UT

February 2011 Update on Preterm Labor and PROM

University of Utah 52nd Annual Ob/Gyn Update, Park City, UT

February 2012 “Antenatal Testing”

“Progesterone for the Prevention of Preterm Birth Update”

University of Utah 53rd Annual Ob/Gyn Update, Park City, UT

August 2012 Advanced Fetal Monitoring

SOGH Annual Clinical Meeting, Denver, CO

February 2013 Delivery at the Time of Viability: Update on Management of the Very Preterm Birth

University of Utah 54th Annual Ob/Gyn Update, Park City, UT

May 2013 Personalized Health Care for Women at the Highest Risk for Pre-term Birth

University of Utah Woman and Child Spring Research Conference,

“Personalizing Our Population’s Health”

Salt Lake City, UT

August 2013 Advanced Fetal Monitoring

SOGH Annual Clinical Meeting, Denver, CO

August 2014 Advanced Fetal Monitoring

SOGH Annual Clinical Meeting, Denver, CO

August 2015 Advanced Fetal Monitoring

SOGH Annual Clinical Meeting, Phoenix, AZ

August 2016 Advanced Fetal Monitoring

SOGH Annual Clinical Meeting, Boulder, CO

Invited / Visiting Professor Presentations

National

March 2006 Recent Advances in the Prevention of Preterm Birth: An Evidence Based Approach to the Management of Preterm Labor

74th Annual Postgraduate Convention, Loma Linda University Medical Center, CA

Grand Rounds

January 1997 Immunosuppressive Therapy in Pregnancy